Article
RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population.
The Journal of clinical endocrinology and metabolism - 1 Jul 2004
Elisei Rossella, Cosci Barbara, Romei Cristina, Bottici Valeria, Sculli Mariangela, Lari Riccardo, Barale Roberto, Pacini Furio, Pinchera Aldo
Abstract excerpt
The RET protooncogene is constitutively activated by point mutations in hereditary medullary thyroid carcinomas (MTCs). RET somatic point mutations have also been reported in 40-50% of sporadic MTCs. Several single nucleotide polymorphisms of the RET gene have been described in the general population as well as in patients with MTC. These allelic variants do not seem to confer any transforming activity to the...
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