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Article

Polymorphisms Within the RET Proto-Oncogene and Risk of Sporadic Medullary Thyroid Carcinoma.

Thyroid : official journal of the American Thyroid Association - 1 Nov 2020

Gemignani Federica, Romei Cristina, Ciampi Raffaele, Corrado Alda, Melaiu Ombretta, Figlioli Gisella, Bonotti Alessandra, Foddis Rudy, Cristaudo Alfonso, Pellegrini Giovanni, Vivaldi Agnese, Cipollini Monica, Landi Stefano, Elisei Rossella

Abstract excerpt

Background: Sporadic medullary thyroid carcinoma (sMTC) is an uncommon neoplasia arising from the calcitonin-producing parafollicular cells of the thyroid. Previous studies evaluated whether single nucleotide polymorphisms (SNPs) within RET (a pivotal proto-oncogene for this disease) are associated with the risk for developing sMTC, but the results are inconclusive. Methods: In this work, we evaluated the...

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PMID: 32228166
DOI: 10.1089/thy.2019.0352

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