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Article

Additive effect of RET polymorphisms on sporadic medullary thyroid carcinoma susceptibility and tumor aggressiveness.

European journal of endocrinology - 1 May 2012

Ceolin Lucieli, Siqueira Débora Rodrigues, Ferreira Carla Vaz, Romitti Mírian, Maia Silvana Cavalcante, Leiria Leonardo, Crispim Daisy, Ashton-Prolla Patrícia, Prolla Patrícia Ashton, Maia Ana Luiza

Abstract excerpt

OBJECTIVE: RET single nucleotide polymorphisms (SNPs) have been implicated in the pathogenesis and progression of medullary thyroid carcinoma (MTC). Here, we investigated the influence of multiple RET variants (G691S, L769L, S836S, and S904S) on the risk of MTC and tumor behavior. DESIGN AND METHODS: One hundred and seven MTC patients and 308 cancer-unaffected control individuals were included. SNPs were analyzed...

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Share to Carcinoma, Neuroendocrine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22345297
DOI: 10.1530/EJE-11-1060

Genes

RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Additive effect of RET polymorphisms on sporadic medullary thyroid carcinoma susceptibility and tumor aggressiveness.PMID 22345297Read ↗

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