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Article

The RET polymorphic allele S836S is associated with early metastatic disease in patients with hereditary or sporadic medullary thyroid carcinoma.

Endocrine-related cancer - 1 Dec 2010

Siqueira Débora R, Romitti Mírian, da Rocha Andreia P, Ceolin Lucieli, Meotti Camila, Estivalet Aline, Puñales Marcia K, Maia Ana Luiza

Abstract excerpt

The possible role of RET variants in modifying the natural course of medullary thyroid carcinoma (MTC) is still a matter of debate. Here, we investigate whether the RET variants L769L, S836S, and G691S/S904S influence disease presentation in hereditary or sporadic MTC patients. One hundred and two patients with hereditary MTC and 81 patients with sporadic MTC attending our institution were evaluated. The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20801952
DOI: 10.1677/ERC-09-0312

Genes

RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RET polymorphic allele S836S is associated with early metastatic disease in patients with hereditary or sporadic medullary thyroid carcinoma.PMID 20801952Read ↗

Germline sequence variant S836S in the RET proto-oncogene is associated with low level predisposition to sporadic medullary thyroid carcinoma in the Spanish population.Semantic proximity Read ↗

Additive effect of RET polymorphisms on sporadic medullary thyroid carcinoma susceptibility and tumor aggressiveness.Semantic proximity Read ↗

Does the RET variant G691S influence the features of sporadic medullary thyroid carcinoma?Semantic proximity Read ↗

Significance of the RET proto-oncogene polymorphisms in Turkish sporadic medullary thyroid carcinoma patients.Semantic proximity Read ↗

Do Prognostic Differences Exist Among High-Risk RET Mutations? A Comparison of Outcomes Between the RET C634R and Other C634 Mutations in Hereditary Medullary Thyroid Carcinoma.Semantic proximity Read ↗

Clinical relevance of RET variants G691S, L769L, S836S and S904S to sporadic medullary thyroid cancerSemantic proximity Read ↗

Quantitative assessment of the association between L769L and S836S polymorphisms at RET gene and medullary thyroid carcinoma risk.Semantic proximity Read ↗

RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population.Semantic proximity Read ↗

The frequency of selected polymorphic variants of the RET gene in patients with medullary thyroid carcinoma and in the general population of central Poland.Semantic proximity Read ↗

Over-representation of a germline RET sequence variant in patients with sporadic medullary thyroid carcinoma and somatic RET codon 918 mutation.Semantic proximity Read ↗

Combined RET and Ki-67 assessment in sporadic medullary thyroid carcinoma: a useful tool for patient risk stratification.Semantic proximity Read ↗

Molecular basis of medullary thyroid carcinoma: the role of RET polymorphisms.Semantic proximity Read ↗

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