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Article

Polymorphisms in the initiators of RET (rearranged during transfection) signaling pathway and susceptibility to sporadic medullary thyroid carcinoma.

The Journal of clinical endocrinology and metabolism - 1 Nov 2005

Cebrian Arancha, Lesueur Fabienne, Martin Sam, Leyland Jean, Ahmed Shahana, Luccarini Craig, Smith Paula L, Luben Robert, Whittaker Joanne, Pharoah Paul D, Dunning Alison M, Ponder Bruce A J

Abstract excerpt

CONTEXT: Medullary thyroid carcinoma (MTC) is a characteristic tumor occurring in individuals with multiple endocrine neoplasia type 2 who carry germ-line mutations in RET (rearranged during transfection). However, most MTC occur in individuals without a family history. OBJECTIVES: The objective of this study was to explore the possibility that susceptibility in these cases results from low penetrance alleles of...

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Share to Glial Cell Line-Derived Neurotrophic Factor Receptors

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Source

Identifiers

PMID: 16091499
DOI: 10.1210/jc.2004-2449

Genes

RET

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in the initiators of RET (rearranged during transfection) signaling pathway and susceptibility to sporadic medullary thyroid carcinoma.PMID 16091499Read ↗

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Does the RET variant G691S influence the features of sporadic medullary thyroid carcinoma?Semantic proximity Read ↗

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Polymorphisms in RET and its coreceptors and ligands as genetic modifiers of multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

Additive effect of RET polymorphisms on sporadic medullary thyroid carcinoma susceptibility and tumor aggressiveness.Semantic proximity Read ↗

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