Comprehensive assessment of the disputed RET Y791F variant shows no association with medullary thyroid carcinoma susceptibility.

doi:10.1530/ERC-14-0491

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Article

Comprehensive assessment of the disputed RET Y791F variant shows no association with medullary thyroid carcinoma susceptibility.

Endocrine-related cancer - 1 Feb 2015

Toledo Rodrigo A, Hatakana Roxanne, Lourenço Delmar M, Lindsey Susan C, Camacho Cleber P, Almeida Marcio, Lima José V, Sekiya Tomoko, Garralda Elena, Naslavsky Michel S, Yamamoto Guilherme L, Lazar Monize, Meirelles Osorio, Sobreira Tiago J P, Lebrao Maria Lucia, Duarte Yeda A O, Blangero John, Zatz Mayana, Cerutti Janete M, Maciel Rui M B, Toledo Sergio P A

Abstract excerpt

Accurate interpretation of germline mutations of the rearranged during transfection (RET) proto-oncogene is vital for the proper recommendation of preventive thyroidectomy in medullary thyroid carcinoma (MTC)-prone carriers. To gain information regarding the most disputed variant of RET, ATA-A Y791F, we sequenced blood DNA samples from a cohort of 2904 cancer-free elderly individuals (1261 via Sanger sequencing...

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PMID: 25425582
DOI: 10.1530/ERC-14-0491
PMCID: PMC4289937

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Comprehensive assessment of the disputed RET Y791F variant shows no association with medullary thyroid carcinoma susceptibility.PMID 25425582Read ↗

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