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Article

The involvement of the RET variant G691S in medullary thyroid carcinoma enlightened by a meta-analysis study.

International journal of cancer - 15 Jun 2013

Lantieri Francesca, Caroli Francesco, Ceccherini Isabella, Griseri Paola

Abstract excerpt

Medullary thyroid carcinoma (MTC) is a rare tumor, partially explained by mutations in the rearranged during transfection (RET) proto-oncogene. The nonsynonymous RET polymorphism G691S has been reported as associated with MTC, but findings are discordant. We sought to clarify the role of G691S in MTCs through in silico analysis, genetic association in our patients and a meta-analysis with extensive literature...

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Source

Identifiers

PMID: 23180660
DOI: 10.1002/ijc.27967

Genes

RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The involvement of the RET variant G691S in medullary thyroid carcinoma enlightened by a meta-analysis study.PMID 23180660Read ↗

RET genotypes in sporadic medullary thyroid cancer: studies in a large Italian series.Semantic proximity Read ↗

The modifier role of RET-G691S polymorphism in hereditary medullary thyroid carcinoma: functional characterization and expression/penetrance studies.Semantic proximity Read ↗

Possible Impact of RET Polymorphism and Its Haplotypic Association Modulates the Susceptibility to Thyroid Cancer.Semantic proximity Read ↗

RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population.Semantic proximity Read ↗

Clinical relevance of RET variants G691S, L769L, S836S and S904S to sporadic medullary thyroid cancerSemantic proximity Read ↗

Comprehensive assessment of the disputed RET Y791F variant shows no association with medullary thyroid carcinoma susceptibility.Semantic proximity Read ↗

Does the RET variant G691S influence the features of sporadic medullary thyroid carcinoma?Semantic proximity Read ↗

Additive effect of RET polymorphisms on sporadic medullary thyroid carcinoma susceptibility and tumor aggressiveness.Semantic proximity Read ↗

Association of RET genetic polymorphisms and haplotypes with papillary thyroid carcinoma in the Portuguese population: a case-control study.Semantic proximity Read ↗

Nationwide French Study of RET Variants Detected from 2003 to 2013 Suggests a Possible Influence of Polymorphisms as Modifiers.Semantic proximity Read ↗

Medullary thyroid carcinoma (MTC) and RET proto-oncogene: mutation spectrum in the familial cases and a meta-analysis of studies on the sporadic form.Semantic proximity Read ↗

The frequency of selected polymorphic variants of the RET gene in patients with medullary thyroid carcinoma and in the general population of central Poland.Semantic proximity Read ↗

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