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Article

Does the RET variant G691S influence the features of sporadic medullary thyroid carcinoma?

Clinical endocrinology - 1 Sept 2008

Cardot-Bauters C, Leteurtre E, Leclerc L, Vantyghem M-C, Do Cao C, Wemeau J-L, d'Herbomez M, Carnaille B, Barbu V, Pinson S, Pigny P

Abstract excerpt

OBJECTIVE: The RET (rearranged during transfection) proto-oncogene G691S variant is over-represented in the germline of patients with sporadic medullary thyroid carcinoma (sMTC) vs. normal controls but so far is not associated with any medical or pathological features of the tumour. The aim of our study was to assess the influence of this variant on the age of onset, clinical, biological and pathological features...

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Source

Identifiers

PMID: 18331611
DOI: 10.1111/j.1365-2265.2008.03230.x

Genes

RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Does the RET variant G691S influence the features of sporadic medullary thyroid carcinoma?PMID 18331611Read ↗

Polymorphisms Within the RET Proto-Oncogene and Risk of Sporadic Medullary Thyroid Carcinoma.Semantic proximity Read ↗

Clinical relevance of RET variants G691S, L769L, S836S and S904S to sporadic medullary thyroid cancerSemantic proximity Read ↗

RET genotypes in sporadic medullary thyroid cancer: studies in a large Italian series.Semantic proximity Read ↗

RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population.Semantic proximity Read ↗

The involvement of the RET variant G691S in medullary thyroid carcinoma enlightened by a meta-analysis study.Semantic proximity Read ↗

The influence of gender, age, and RET polymorphisms on C-cell hyperplasia and medullary thyroid carcinoma.Semantic proximity Read ↗

Medullary thyroid carcinoma (MTC) and RET proto-oncogene: mutation spectrum in the familial cases and a meta-analysis of studies on the sporadic form.Semantic proximity Read ↗

The RET polymorphic allele S836S is associated with early metastatic disease in patients with hereditary or sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

The frequency of selected polymorphic variants of the RET gene in patients with medullary thyroid carcinoma and in the general population of central Poland.Semantic proximity Read ↗

Additive effect of RET polymorphisms on sporadic medullary thyroid carcinoma susceptibility and tumor aggressiveness.Semantic proximity Read ↗

Molecular Basis and Natural History of Medullary Thyroid Cancer: It is (Almost) All in the RETSemantic proximity Read ↗

The modifier role of RET-G691S polymorphism in hereditary medullary thyroid carcinoma: functional characterization and expression/penetrance studies.Semantic proximity Read ↗

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