Article
Opposing roles in neurite growth control by two seven-pass transmembrane cadherins.
Nature neuroscience - 1 Aug 2007
Shima Yasuyuki, Kawaguchi Shin-ya, Kosaka Kazuyoshi, Nakayama Manabu, Hoshino Mikio, Nabeshima Yoichi, Hirano Tomoo, Uemura Tadashi
Abstract excerpt
The growth of neurites (axon and dendrite) should be appropriately regulated by their interactions in the development of nervous systems where a myriad of neurons and their neurites are tightly packed. We show here that mammalian seven-pass transmembrane cadherins Celsr2 and Celsr3 are activated by their homophilic interactions and regulate neurite growth in an opposing manner. Both gene-silencing and coculture...
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