Article
Regulation of neurite outgrowth in N1E-115 cells through PDZ-mediated recruitment of diacylglycerol kinase zeta.
Molecular and cellular biology - 1 Aug 2005
Yakubchyk Yury, Abramovici Hanan, Maillet Jean-Christian, Daher Elias, Obagi Christopher, Parks Robin J, Topham Matthew K, Gee Stephen H
Abstract excerpt
Syntrophins are scaffold proteins that regulate the subcellular localization of diacylglycerol kinase zeta (DGK-zeta), an enzyme that phosphorylates the lipid second-messenger diacylglycerol to yield phosphatidic acid. DGK-zeta and syntrophins are abundantly expressed in neurons of the developing and adult brain, but their function is unclear. Here, we show that they are present in cell bodies, neurites, and...
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