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Article

14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.

Human molecular genetics - 1 Jan 2016

Lavalley Nicholas J, Slone Sunny R, Ding Huiping, West Andrew B, Yacoubian Talene A

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common known cause of inherited Parkinson's disease (PD), and LRRK2 is a risk factor for idiopathic PD. How LRRK2 function is regulated is not well understood. Recently, the highly conserved 14-3-3 proteins, which play a key role in many cellular functions including cell death, have been shown to interact with LRRK2. In this study, we investigated...

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Identifiers

PMID: 26546614
DOI: 10.1093/hmg/ddv453
PMCID: PMC4690493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.PMID 26546614Read ↗

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14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive stateSemantic proximity Read ↗

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