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Article

Nerve growth factor-mediated neurite outgrowth via regulation of Rab5.

Molecular biology of the cell - 1 Apr 2007

Liu Jay, Lamb Darija, Chou Margaret M, Liu Yong-Jian, Li Guangpu

Abstract excerpt

Nerve growth factor (NGF) induces neurite outgrowth and differentiation in a process that involves NGF binding to its receptor TrkA and endocytosis of the NGF-TrkA complex into signaling endosomes. Here, we find that biogenesis of signaling endosomes requires inactivation of Rab5 to block early endosome fusion. Expression of dominant-negative Rab5 mutants enhanced NGF-mediated neurite outgrowth, whereas a...

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Identifiers

PMID: 17267689
DOI: 10.1091/mbc.e06-08-0725
PMCID: PMC1838971

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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