Article
DISC1 puts the brakes on neurogenesis.
Cell - 21 Sept 2007
Dranovsky Alex, Hen Rene
Abstract excerpt
The gene DISC1 (Disrupted-in-Schizophrenia 1) is a leading candidate gene for schizophrenia. In this issue, Duan et al. (2007) present evidence implicating DISC1 in the maturation and integration of newly generated neurons in the adult mouse hippocampus. Surprisingly, DISC1 appears to have opposite effects on neurogenesis during development and in adulthood.
Topics
- Animals
- Carrier Proteins
- Cell Differentiation
- Cell Lineage
- Cell Movement
- Cell Proliferation
- Cell Size
- Dendrites
- Dentate Gyrus
- Genotype
- Hippocampus
- Mice
- Morphogenesis