Article
Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs.
Human molecular genetics - 15 Apr 2006
Lipska Barbara K, Peters Tricia, Hyde Thomas M, Halim Nader, Horowitz Cara, Mitkus Shruti, Weickert Cynthia Shannon, Matsumoto Mitsuyuki, Sawa Akira, Straub Richard E, Vakkalanka Radhakrishna, Herman Mary M, Weinberger Daniel R, Kleinman Joel E
Abstract excerpt
DISC1 has been identified as a schizophrenia susceptibility gene based on linkage and SNP association studies and clinical data suggesting that risk SNPs impact on hippocampal structure and function. In cell and animal models, C-terminus-truncated DISC1 disrupts intracellular transport, neural architecture and migration, perhaps because it fails to interact with binding partners involved in neuronal...
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