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Article

Role of complement 3a in the synthetic phenotype and angiotensin II-production in vascular smooth muscle cells from spontaneously hypertensive rats.

American journal of hypertension - 1 Mar 2012

Han Ying, Fukuda Noboru, Ueno Takahiro, Endo Morito, Ikeda Kazuya, Xueli Zhou, Matsumoto Taro, Soma Masayoshi, Matsumoto Koichi

Abstract excerpt

BACKGROUND: Spontaneously hypertensive rats (SHR)-derived vascular smooth muscle cells (VSMCs) show exaggerated growth with a synthetic phenotype and angiotensin II (Ang II)-production. To evaluate the contribution of complement 3 (C3) or C3a toward these abnormalities in SHR, we examined effects of a C3a receptor inhibitor on proliferation, phenotype, and Ang II-production in VSMCs from SHR and Wistar-Kyoto...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22089112
DOI: 10.1038/ajh.2011.214
PMCID: PMC3280391

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