The direct effect of fibroblast growth factor 23 on vascular smooth muscle cell phenotype and function.

doi:10.1093/ndt/gfac220

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Article

The direct effect of fibroblast growth factor 23 on vascular smooth muscle cell phenotype and function.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 13 Feb 2023

Vergara Noemi, de Mier M Victoria Pendón-Ruiz, Rodelo-Haad Cristian, Revilla-González Gonzalo, Membrives Cristina, Díaz-Tocados Juan M, Martínez-Moreno Julio M, Torralbo Ana I, Herencia Carmen, Rodríguez-Ortiz María Encarnación, López-Baltanás Rodrigo, Richards Williams G, Felsenfeld Arnold, Almadén Yolanda, Martin-Malo Alejandro, Ureña Juan, Santamaría Rafael, Soriano Sagrario, Rodríguez Mariano, Muñoz-Castañeda Juan R

Abstract excerpt

BACKGROUND: In chronic kidney disease (CKD) patients, increased levels of fibroblast growth factor 23 (FGF23) are associated with cardiovascular mortality. The relationship between FGF23 and heart hypertrophy has been documented, however, it is not known whether FGF23 has an effect on vasculature. Vascular smooth muscle cells VSMCs may exhibit different phenotypes; our hypothesis is that FGF23 favours a switch...

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PMID: 35867864
DOI: 10.1093/ndt/gfac220
PMCID: PMC9923714

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