Article
Expression of V3 Versican by Rat Arterial Smooth Muscle Cells Promotes Differentiated and Anti-inflammatory Phenotypes.
The Journal of biological chemistry - 28 Aug 2015
Kang Inkyung, Barth Jeremy L, Sproul Erin P, Yoon Dong Won, Workman Gail A, Braun Kathleen R, Argraves W Scott, Wight Thomas N
Abstract excerpt
Arterial smooth muscle cells (ASMCs) undergo phenotypic changes during development and pathological processes in vivo and during cell culture in vitro. Our previous studies demonstrated that retrovirally mediated expression of the versican V3 splice variant (V3) by ASMCs retards cell proliferation and migration in vitro and reduces neointimal thickening and macrophage and lipid accumulation in animal models of...
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