Growth characteristics, angiotensin II generation, and microarray-determined gene expression in vascular smooth muscle cells from young spontaneously hypertensive rats.

Abstract excerpt

BACKGROUND: We have demonstrated that vascular smooth muscle cells (VSMCs) derived from spontaneously hypertensive rats (SHR) show exaggerated growth and produce angiotensin (Ang) II and growth factors. These may reflect intrinsic abnormalities in SHR that are not caused by excessive blood pressure, and are associated with genetic abnormalities. OBJECTIVE: To evaluate whether these characteristics of VSMCs from...

Topics

• Age Factors
• Angiotensin II
• Animals
• Blood Pressure
• Disease Models, Animal
• Gene Expression Profiling
• Genetic Markers
• Genetic Predisposition to Disease
• Intercellular Signaling Peptides and Proteins
• Male
• Models, Cardiovascular
• Muscle, Smooth, Vascular