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Article

Determinants of Notch-3 Receptor Expression and Signaling in Vascular Smooth Muscle Cells

28 Nov 2002

Abstract excerpt

The Notch family of receptors and ligands plays an important role in cell fate determination, vasculogenesis, and organogenesis. Mutations of the Notch-3 receptor result in an arteriopathy that predisposes to early-onset stroke. However, the functional role of the Notch signaling pathway in adult vascular smooth muscle cells (VSMCs) is poorly characterized. This study documents that the Notch-3 receptor, the...

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PMID: 12456485
DOI: 10.1161/01.res.0000044944.99984.25

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