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Article

Inactivation of the Lipopeptide Antibiotic Daptomycin by Hydrolytic Mechanisms

15 Nov 2011

Abstract excerpt

The lipopeptide daptomycin is a member of the newest FDA-approved antimicrobial class, exhibiting potency against a broad range of Gram-positive pathogens with only rare incidences of clinical resistance. Environmental bacteria harbor an abundance of resistance determinants orthologous to those in pathogens and thus may serve as an early-warning system for future clinical emergence. A collection of...

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PMID: 22083474
DOI: 10.1128/aac.05441-11

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