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Biosynthesis and Genetic Engineering of Lipopeptide Antibiotics Related to Daptomycin

30 Apr 2008

Abstract excerpt

Daptomycin is a clinically important antibiotic approved for the treatment of complicated skin and skin structure infections caused by Gram-positive pathogens, and for the treatment of bacteremia and endocarditis caused by Staphylococcus aureus. Daptomycin and related acidic cyclic lipopeptide antibiotics have ten amino acids in the ring, and exocyclic tails containing one or three amino acids. The N-termini of...

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PMID: 18473888
DOI: 10.2174/156802608784221497

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