Article
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics.
Nature medicine - 1 Oct 2005
Brötz-Oesterhelt Heike, Beyer Dieter, Kroll Hein-Peter, Endermann Rainer, Ladel Christoph, Schroeder Werner, Hinzen Berthold, Raddatz Siegfried, Paulsen Holger, Henninger Kerstin, Bandow Julia E, Sahl Hans-Georg, Labischinski Harald
Abstract excerpt
Here we show that a new class of antibiotics-acyldepsipeptides-has antibacterial activity against Gram-positive bacteria in vitro and in several rodent models of bacterial infection. The acyldepsipeptides are active against isolates that are resistant to antibiotics in clinical application, implying a new target, which we identify as ClpP, the core unit of a major bacterial protease complex. ClpP is usually...
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