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Article

Dysregulation of bacterial proteolytic machinery by a new class of antibiotics.

Nature medicine - 1 Oct 2005

Brötz-Oesterhelt Heike, Beyer Dieter, Kroll Hein-Peter, Endermann Rainer, Ladel Christoph, Schroeder Werner, Hinzen Berthold, Raddatz Siegfried, Paulsen Holger, Henninger Kerstin, Bandow Julia E, Sahl Hans-Georg, Labischinski Harald

Abstract excerpt

Here we show that a new class of antibiotics-acyldepsipeptides-has antibacterial activity against Gram-positive bacteria in vitro and in several rodent models of bacterial infection. The acyldepsipeptides are active against isolates that are resistant to antibiotics in clinical application, imply...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16200071
DOI: 10.1038/nm1306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16200071-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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