Article

Cyclic lipopeptide natural products as taxa-specific antibacterial inhibitors of the lipid II flippase

2025-10-03

Abstract excerpt

Antimicrobial resistance (AMR) is an existential threat to modern healthcare; one fueled by selection pressure provided by the use of broad-spectrum antibiotics in medicine and agriculture. As these antibiotics rely on a small set of chemical scaffolds and affect an even smaller number of biological targets, emergent AMR genes can spread through microbiomes to simultaneously inactivate multiple classes and generat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bff87f96-27f5-5ec3-b942-9a20fcb120bc
DOI: 10.1101/2025.10.02.680127

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cyclic lipopeptide natural products as taxa-specific antibacterial inhibitors of the lipid II flippaseDOI 10.1101/2025.10.02.680127Read

Bioinformatic prospecting and synthesis of a bifunctional lipopeptide antibiotic that evades resistanceSemantic proximity Read

Human Microbiome Inspired Antibiotics with Improved β-Lactam Synergy against MDR Staphylococcus aureusSemantic proximity Read

A novel antibiotic class targeting the lipopolysaccharide transporterSemantic proximity Read

Antibiotics and resistance: the two-sided coin of the mycobacterial cell wallSemantic proximity Read

Discovery, synthesis, and optimization of teixobactin, a novel antibiotic without detectable bacterial resistanceSemantic proximity Read

Initial Efforts toward the Optimization of Arylomycins for Antibiotic ActivitySemantic proximity Read

Cyclic Lipodepsipeptides: A New Class of Antibacterial Agents in the Battle Against Resistant BacteriaSemantic proximity Read

A Synthetic Antibiotic Scaffold Effective Against Multidrug-Resistant Bacterial PathogensSemantic proximity Read

A Broad Spectrum Lasso Peptide Antibiotic Targeting the Bacterial RibosomeSemantic proximity Read

Peptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosa.Semantic proximity Read

Dissecting the collateral damage of antibiotics on gut microbesSemantic proximity Read

Opportunities for Synthetic Biology in Antibiotics: Expanding Glycopeptide Chemical DiversitySemantic proximity Read