Article

Targeted Modification of the Antimicrobial Peptide DGL13K Reveals a Naturally Optimized Sequence for Topical Applications

2025-09-18

Abstract excerpt

<h4>ABSTRACT</h4> Antimicrobial peptides are potential alternatives to conventional antibiotics, primarily due broad spectrum activity and low propensity for inducing bacterial resistance. However, their clinical translation faces challenges, including peptide stability and potential mammalian cell toxicity. This study centers on DGL13K, an all D-amino acid peptide, which overcomes proteolytic susceptibility and...

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Literature Corpus work: 3d3763bb-ad67-58b2-b5fd-c59df27706a6
DOI: 10.1101/2025.09.16.676538

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