Article
Different groups of metabolic genes cluster around early and late firing origins of replication in budding yeast.
Genome informatics. International Conference on Genome Informatics - 1 Jan 2010
Spiesser Thomas W, Klipp Edda
Abstract excerpt
DNA replication is a fundamental process that is tightly regulated during the cell cycle. In budding yeast it starts from multiple origins of replication and proceeds in a timely fashion according to a reproducible temporal program until the entire DNA is replicated exactly once per cell cycle. In this program an origin seems to have an inherent firing probability at a specific time in S-phase that is conserved...
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