Article
Combined point mutations in codon 12 and 13 of KRAS oncogene in prostate carcinomas.
Molecular biology reports - 1 Feb 2012
Silan Fatma, Gultekin Yener, Atik Sinem, Kilinc Davran, Alan Cabir, Yildiz Fazilet, Uludag Ahmet, Ozdemir Ozturk
Abstract excerpt
Prostate cancer is a common malignancy that develops by structural mutation(s) and/or other genetic alterations in specific genes.The G to T transversions in codon 12 and C to T transitions in codon 13 of KRAS proto-oncogene are predominant point mutations that occur in about 20% of different cancers in human. In the current study it was aimed to investigate the prevalence and predictive significance of KRAS...
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