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Article

Totipotency and lineage segregation in the human embryo

3 Apr 2014

Abstract excerpt

During human preimplantation development the totipotent zygote divides and undergoes a number of changes that lead to the first lineage differentiation in the blastocyst displaying trophectoderm (TE) and inner cell mass (ICM) on Day 5. The TE is a differentiated epithelium needed for implantation and the ICM forms the embryo proper and serves as a source for pluripotent embryonic stem cells (ESCs). The blastocyst...

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PMID: 24699365
DOI: 10.1093/molehr/gau027

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