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Evidence implicating sequential commitment of the founder lineages in the human blastocyst by order of hypoblast gene activation

27 Apr 2023

Abstract excerpt

Successful human pregnancy depends upon rapid establishment of three founder lineages: the trophectoderm, epiblast and hypoblast, which together form the blastocyst. Each plays an essential role in preparing the embryo for implantation and subsequent development. Several models have been proposed to define the lineage segregation. One suggests that all lineages specify simultaneously; another favours the...

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PMID: 37102672
DOI: 10.1242/dev.201522

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