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Article

Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation.

The Journal of biological chemistry - 2 Nov 2012

Visweswaraiah Jyothsna, Lee Su Jung, Hinnebusch Alan G, Sattlegger Evelyn

Abstract excerpt

In eukaryotes, phosphorylation of translation initiation factor 2α (eIF2α) by the kinase Gcn2 (general control nonderepressible 2) is a key response to amino acid starvation. Sensing starvation requires that Gcn2 directly contacts its effector protein Gcn1, and both must contact the ribosome. We have proposed that Gcn2 is activated by uncharged tRNA bound to the ribosomal decoding (A) site, in a manner...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22888004
DOI: 10.1074/jbc.M112.368266
PMCID: PMC3488051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation.PMID 22888004Read ↗

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