Article
Mutations in transmembrane domain of c-erbB-2 gene in human malignant tumours of the central nervous system.
Neurological research - 1 Jun 1992
Kamitani H, Mariyama M, Hori T, Nishimura S
Abstract excerpt
Point mutations in the transmembrane domain of c-erbB-2 gene in human brain tumours were studied by DNA amplification with the polymerase chain reaction method. Amplified gene fragments in M13 phage vector were cloned, and subsequent nucleotide sequences were determined. Studied specimens were 10 human malignant and 3 human benign tumours of the central nervous system, and a normal human placenta. In malignant...
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