Mutations in transmembrane domain of c-erbB-2 gene in human malignant tumours of the central nervous system.

doi:10.1080/01616412.1992.11740061

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Article

Mutations in transmembrane domain of c-erbB-2 gene in human malignant tumours of the central nervous system.

Neurological research - 1 Jun 1992

Kamitani H, Mariyama M, Hori T, Nishimura S

Abstract excerpt

Point mutations in the transmembrane domain of c-erbB-2 gene in human brain tumours were studied by DNA amplification with the polymerase chain reaction method. Amplified gene fragments in M13 phage vector were cloned, and subsequent nucleotide sequences were determined. Studied specimens were 10...

Topics

Amino Acid Sequence
Base Sequence
Brain Neoplasms
Cell Membrane
Codon
Female
Humans
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Placenta
Pregnancy
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Receptor, ErbB-2

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