Article
Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer.
Oncogene - 1 Feb 1990
Lemoine N R, Staddon S, Dickson C, Barnes D M, Gullick W J
Abstract excerpt
The rat neu proto-oncogene, which is a putative growth factor receptor closely related to the epidermal growth factor receptor, can be activated in vivo by a single point mutation in the sequence encoding its transmembrane region. The human homologue of neu, c-erbB-2, can be activated in vitro to an oncogenic form by point mutations in the same relative position in the gene. We have sought the presence of such...
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