Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Home and away- the evolutionary dynamics of homing endonucleases.

BMC evolutionary biology - 4 Nov 2011

Barzel Adi, Obolski Uri, Gogarten Johann Peter, Kupiec Martin, Hadany Lilach

Abstract excerpt

BACKGROUND: Homing endonucleases (HEases) are a large and diverse group of site-specific DNAases. They reside within self-splicing introns and inteins, and promote their horizontal dissemination. In recent years, HEases have been the focus of extensive research due to their promising potential use in gene targeting procedures for the treatment of genetic diseases and for the genetic engineering of crop, animal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Computer Simulation
Share to Endonucleases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Introns

Share to Models, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 22054298
DOI: 10.1186/1471-2148-11-324
PMCID: PMC3229294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Home and away- the evolutionary dynamics of homing endonucleases.PMID 22054298Read ↗

Evolutionary maintenance of selfish homing endonuclease genes in the absence of horizontal transfer.Semantic proximity Read ↗

Tapping natural reservoirs of homing endonucleases for targeted gene modificationSemantic proximity Read ↗

Homing endonucleases: DNA scissors on a mission.Semantic proximity Read ↗

Homing endonucleases residing within inteins: evolutionary puzzles awaiting genetic solutions.Semantic proximity Read ↗

Native homing endonucleases can target conserved genes in humans and in animal models.Semantic proximity Read ↗

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito.Semantic proximity Read ↗

Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets.Semantic proximity Read ↗

Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing.Semantic proximity Read ↗

Requirements for effective malaria control with homing endonuclease genesSemantic proximity Read ↗

Control of catalytic efficiency by a coevolving network of catalytic and noncatalytic residues.Semantic proximity Read ↗

Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation.Semantic proximity Read ↗

Degeneration of a homing endonuclease and its target sequence in a wild yeast strain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.