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Article

Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing.

Genetics - 1 Apr 2017

Beaghton Andrea, Hammond Andrew, Nolan Tony, Crisanti Andrea, Godfray H Charles J, Burt Austin

Abstract excerpt

There is a need for new interventions against the ongoing burden of vector-borne diseases such as malaria and dengue. One suggestion has been to develop genes encoding effector molecules that block parasite development within the vector, and then use the nuclease-based homing reaction as a form of gene drive to spread those genes through target populations. If the effector gene reduces the fitness of the mosquito...

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Identifiers

PMID: 28159753
DOI: 10.1534/genetics.116.197632
PMCID: PMC5378115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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