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Article

Requirements for effective malaria control with homing endonuclease genes

5 Oct 2011

Abstract excerpt

Malaria continues to impose a substantial burden on human health. We have previously proposed that biological approaches to control the mosquito vector of disease could be developed using homing endonuclease genes (HEGs), a class of selfish or parasitic gene that exists naturally in many microbes. Recent lab studies have demonstrated that HEGs can function in mosquitoes. We constructed and analyzed a model of...

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PMID: 21976487
DOI: 10.1073/pnas.1110717108

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