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Article

An unstructured 5'-coding region of the prfA mRNA is required for efficient translation.

Nucleic acids research - 1 Feb 2012

Loh Edmund, Memarpour Faranak, Vaitkevicius Karolis, Kallipolitis Birgitte H, Johansson Jörgen, Sondén Berit

Abstract excerpt

Expression of virulence factors in the human bacterial pathogen Listeria monocytogenes is almost exclusively regulated by the transcriptional activator PrfA. The translation of prfA is controlled by a thermosensor located in the 5'-untranslated RNA (UTR), and is high at 37°C and low at temperatures <30°C. In order to develop a thermoregulated translational expression system, the 5'-UTR and different lengths of...

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Identifiers

PMID: 22053088
DOI: 10.1093/nar/gkr850
PMCID: PMC3287183

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