Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An RNA thermosensor controls expression of virulence genes in Listeria monocytogenes.

Cell - 6 Sept 2002

Johansson Jörgen, Mandin Pierre, Renzoni Adriana, Chiaruttini Claude, Springer Mathias, Cossart Pascale

Abstract excerpt

In Listeria monocytogenes, virulence genes are maximally expressed at 37 degrees C, almost silent at 30 degrees C and controlled by PrfA, a transcriptional activator whose expression is thermoregulated. Here, we show that the untranslated mRNA (UTR) preceding prfA, forms a secondary structure, which masks the ribosome binding region. Mutations predicted to destabilize this structure led to virulence gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Bacterial
Share to Listeria monocytogenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleic Acid Conformation

Share to Peptide Termination Factors

Share to Ribosomes

Share to RNA Processing, Post-Transcriptional

Share to RNA, Untranslated

Share to Trans-Activators

Source

Identifiers

PMID: 12230973
DOI: 10.1016/s0092-8674(02)00905-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An RNA thermosensor controls expression of virulence genes in Listeria monocytogenes.PMID 12230973Read ↗

An unstructured 5'-coding region of the prfA mRNA is required for efficient translation.Semantic proximity Read ↗

A Tale of Two Transitions: The Unfolding Mechanism of the prfA RNA Thermosensor.Semantic proximity Read ↗

Localized ribosome access and distal tuning via the <i>Listeria prfA</i> RNA thermometerSemantic proximity Read ↗

Temperature-responsive in vitro RNA structurome of <i>Yersinia pseudotuberculosis</i>Semantic proximity Read ↗

SHAPE analysis of the htrA RNA thermometer from Salmonella enterica.Semantic proximity Read ↗

Temperature-controlled structural alterations of an RNA thermometer.Semantic proximity Read ↗

Functional impact of mutational activation on the Listeria monocytogenes central virulence regulator PrfA.Semantic proximity Read ↗

Isolation of Listeria monocytogenes mutants with high-level in vitro expression of host cytosol-induced gene products.Semantic proximity Read ↗

A naturally occurring mutation K220T in the pleiotropic activator PrfA of Listeria monocytogenes results in a loss of virulence due to decreasing DNA-binding affinity.Semantic proximity Read ↗

Characterization of a large motility gene cluster containing the cheR, motAB genes of Listeria monocytogenes and evidence that PrfA downregulates motility genes.Semantic proximity Read ↗

A novel mutation within the central Listeria monocytogenes regulator PrfA that results in constitutive expression of virulence gene products.Semantic proximity Read ↗

The intracellular sRNA transcriptome of Listeria monocytogenes during growth in macrophages.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.