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Article

A Tale of Two Transitions: The Unfolding Mechanism of the prfA RNA Thermosensor.

Biochemistry - 8 Dec 2020

Zhang Huaqun, Hall Ian, Nissley Amos J, Abdallah Kyrillos, Keane Sarah C

Abstract excerpt

RNA thermosensors (RNATs), found in the 5' untranslated region (UTR) of some bacterial messenger RNAs (mRNAs), control the translation of the downstream gene in a temperature-dependent manner. In Listeria monocytogenes, the expression of a key transcription factor, PrfA, is mediated by an RNAT in its 5' UTR. PrfA functions as a master regulator of virulence in L. monocytogenes, controlling the expression of many...

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PMID: 33231432
DOI: 10.1021/acs.biochem.0c00588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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