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Article

Chronic inflammatory cardiomyopathy of interferon γ-overexpressing transgenic mice is mediated by tumor necrosis factor-α.

The American journal of pathology - 1 Jan 2012

Torzewski Michael, Wenzel Philip, Kleinert Hartmut, Becker Christoph, El-Masri Jasmin, Wiese Elena, Brandt Moritz, Pautz Andrea, Twardowski Laura, Schmitt Edgar, Münzel Thomas, Reifenberg Kurt

Abstract excerpt

We recently described a model of inflammatory cardiomyopathy in interferon (IFN)-γ overexpressing transgenic mice stably circulating IFN-γ in the serum referred to as SAP--IFN-γ mice. SAP-IFN-γ transgenic mice show cardiac infiltration by mononuclear leukocytes, culminating in dilated cardiomyopathy characterized by an increase of left ventricular end diastolic diameter and reduction of fractional shortening. We...

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PMID: 22051774
DOI: 10.1016/j.ajpath.2011.09.006

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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