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Article

Novel model of constrictive pericarditis associated with autoimmune heart disease in interferon-gamma-knockout mice.

Circulation - 2 Nov 2004

Afanasyeva Marina, Georgakopoulos Dimitrios, Fairweather DeLisa, Caturegli Patrizio, Kass David A, Rose Noel R

Abstract excerpt

BACKGROUND: Constrictive pericarditis represents a serious hemodynamic syndrome that may lead to heart failure. Studies of its pathophysiological mechanisms have been impeded by the lack of an animal model. METHODS AND RESULTS: Cardiac myosin-induced experimental autoimmune myocarditis in interferon (IFN)-gamma-knockout (KO) mice results in increased cardiac inflammation and development of severe grossly...

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Identifiers

PMID: 15505106
DOI: 10.1161/01.CIR.0000147538.92263.3A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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