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Article

Gene expression profiling during the transition to failure in TNF-alpha over-expressing mice demonstrates the development of autoimmune myocarditis.

Journal of molecular and cellular cardiology - 1 Apr 2004

Tang Zhonghua, McGowan Brian S, Huber Sally A, McTiernan Charles F, Addya Sankar, Surrey Saul, Kubota Toru, Fortina Paolo, Higuchi Yoshihiro, Diamond Maura A, Wyre Dwayne S, Feldman Arthur M

Abstract excerpt

Transgenic mice with cardiac-specific over-expression of tumor necrosis factor-alpha (TNF1.6) progress to dilated heart failure. A significant inflammatory response precedes functional deterioration, and may contribute to cardiac damage in this model. To evaluate the underlying molecular mechanisms, we assessed the gene expression in six groups of mouse hearts defined by age, gender, and phenotype (n = 3/group)...

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Source

Identifiers

PMID: 15081311
DOI: 10.1016/j.yjmcc.2004.01.008

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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