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Article

Cardiac disease in transgenic mice expressing human immunodeficiency virus-1 nef in cells of the immune system.

The American journal of pathology - 1 Jul 2002

Kay Denis G, Yue Ping, Hanna Zaher, Jothy Serge, Tremblay Etienne, Jolicoeur Paul

Abstract excerpt

We previously reported that a severe acquired immune deficiency syndrome-like disease develops in transgenic (Tg) mice expressing the human immunodeficiency virus-1 in its natural target cells: immature and mature CD4(+) T cells and cells of the macrophage/dendritic lineage. Here, we show that these mice also develop cardiac disease, characterized most prominently by a focal myocytolysis, occasionally by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12107117
DOI: 10.1016/S0002-9440(10)64184-3
PMCID: PMC1850688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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