Article
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).
Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2002
Metcalf Donald, Mifsud Sandra, Di Rago Ladina, Nicola Nicos A, Hilton Douglas J, Alexander Warren S
Abstract excerpt
Mice with inactivation of the gene encoding the suppressor of cytokine signaling-1 (SOCS-1) die in neonatal life with an IFN-gamma-dependent inflammatory disease dominated by fatty degeneration and necrosis of the liver. To establish the long-term pathological consequences of loss of SOCS-1 in mice, where initial survival was made possible by also deleting the IFN-gamma gene, a comparison was made of the lifespan...
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