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Heterozygous Interferon Signaling Deficient Mice as Animal Models for Chikungunya Virus Infection in the Heart

2025-04-28

Abstract excerpt

<title>Abstract</title> <p>Although chikungunya virus (CHIKV)-caused cardiovascular diseases are frequently reported in clinics, the underlying mechanisms are poorly understood, which is primarily due to a lack of animal models. In this study, we report that CHIKV infection in homozygous interferon α/β receptor-deficient (<italic>ifnar1</italic><sup><italic>-/-</italic></sup>) and interferon α/β/γ receptor-defici...

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Literature Corpus work: 27ea1c3d-48e1-5623-8884-7892c6c5ce0c
DOI: 10.21203/rs.3.rs-5530552/v1

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