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Article

A nucleosome-positioning sequence is required for GCN4 to activate transcription in the absence of a TATA element.

Molecular and cellular biology - 1 Aug 1990

Brandl C J, Struhl K

Abstract excerpt

In the gal-his3 hybrid promoter his3-GG1, the yeast upstream activator protein GCN4 stimulates transcription when bound at the position normally occupied by the TATA element. This TATA-independent activation by GCN4 requires two additional elements in the gal enhancer region that are distinct from those involved in normal galactose induction. Both additional elements appear to be functionally distinct from a...

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Identifiers

PMID: 2196450
DOI: 10.1128/mcb.10.8.4256-4265.1990
PMCID: PMC360965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A nucleosome-positioning sequence is required for GCN4 to activate transcription in the absence of a TATA element.PMID 2196450Read ↗

TATA-binding protein activates transcription when upstream of a GCN4-binding site in a novel yeast promoter.Semantic proximity Read ↗

Mutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites.Semantic proximity Read ↗

Permanent nucleosome exclusion from the Gal4p-inducible yeast GCY1 promoter.Semantic proximity Read ↗

Gcn4 Binding in Coding Regions Can Activate Internal and Canonical 5' Promoters in Yeast.Semantic proximity Read ↗

Precise nucleosome positioning and the TATA box dictate requirements for the histone H4 tail and the bromodomain factor Bdf1.Semantic proximity Read ↗

The N-terminal and C-terminal domains of RAP1 are dispensable for chromatin opening and GCN4-mediated HIS4 activation in budding yeast.Semantic proximity Read ↗

Activation domain-dependent monoubiquitylation of Gal4 protein is essential for promoter binding in vivo.Semantic proximity Read ↗

Identification of seven hydrophobic clusters in GCN4 making redundant contributions to transcriptional activation.Semantic proximity Read ↗

Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo.Semantic proximity Read ↗

Direct regulation of nucleosome density by the conserved AAA-ATPase Yta7.Semantic proximity Read ↗

Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4.Semantic proximity Read ↗

Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation.Semantic proximity Read ↗

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