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Article

Truncated variants of the GCN4 transcription activator protein bind DNA with dramatically different dynamical motifs.

Journal of chemical information and modeling - 27 Oct 2014

McHarris Danielle M, Barr Daniel A

Abstract excerpt

The yeast protein GCN4 is a transcriptional activator in the basic leucine zipper (bZip) family, whose distinguishing feature is the "chopstick-like" homodimer of alpha helices formed at the DNA-binding interface. While experiments have shown that truncated versions of the protein retain biologically relevant DNA-binding affinity, we present the results of a computational study revealing that these variants show...

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Identifiers

PMID: 25204850
DOI: 10.1021/ci500448e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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