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Article

Identification of seven hydrophobic clusters in GCN4 making redundant contributions to transcriptional activation.

Molecular and cellular biology - 1 Oct 1996

Jackson B M, Drysdale C M, Natarajan K, Hinnebusch A G

Abstract excerpt

GCN4 is a transcriptional activator in the bZIP family that regulates amino acid biosynthetic genes in the yeast Saccharomyces cerevisiae. The N-terminal 100 amino acids of GCN4 contains a potent activation function that confers high-level transcription in the absence of the centrally located acidic activation domain (CAAD) delineated in previous studies. To identify specific amino acids important for activation...

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Identifiers

PMID: 8816468
DOI: 10.1128/MCB.16.10.5557
PMCID: PMC231555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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