Article
A common genetic variant (97906C>A) of DAB2IP/AIP1 is associated with an increased risk and early onset of lung cancer in Chinese males.
PloS one - 1 Jan 2011
Yang Lei, Li Yinyan, Ling Xiaoxuan, Liu Lin, Liu Bin, Xu Kevin, Bin Xiaonong, Ji Weidong, Lu Jiachun
Abstract excerpt
DOC-2/DAB2 interactive protein (DAB2IP) is a novel identified tumor suppressor gene that inhibits cell growth and facilitates cell apoptosis. One genetic variant in DAB2IP gene was reported to be associated with an increased risk of aggressive prostate cancer recently. Since DAB2IP involves in the development of lung cancer and low expression of DAB2IP are observed in lung cancer, we hypothesized that the...
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