Article
Polymorphisms in DNA damage binding protein 2 (DDB2) and susceptibility of primary lung cancer in the Chinese: a case-control study.
Carcinogenesis - 1 Jul 2006
Hu Zhibin, Shao Minhua, Yuan Jing, Xu Liang, Wang Feng, Wang Yi, Yuan Wentao, Qian Ji, Ma Hongxia, Wang Ying, Liu Hongliang, Chen Weihong, Yang Lin, Jin Guangfu, Huo Xiang, Chen Feng, Jin Li, Wei Qingyi, Huang Wei, Lu Daru, Wu Tangchun, Shen Hongbing
Abstract excerpt
DNA damage binding protein 2 (DDB2) is one of the major DNA repair proteins involved in the nucleotide excision repair (NER) pathway. Mutations in the DDB2 gene can cause a repair-deficiency syndrome xeroderma pigmentosum group E. Because tobacco carcinogens can cause DNA damage that is repaired by NER and suboptimal NER capacity is reported to be associated with lung cancer risk, we hypothesized that common...
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