Article
Relationship between Rgs2 gene expression level and anxiety and depression-like behaviour in a mutant mouse model: serotonergic involvement.
The international journal of neuropsychopharmacology - 1 Oct 2012
Lifschytz Tzuri, Broner Esther Channah, Zozulinsky Polina, Slonimsky Alexandra, Eitan Renana, Greenbaum Lior, Lerer Bernard
Abstract excerpt
RGS2 is a member of a family of proteins that negatively modulate G-protein coupled receptor transmission. Variations in the RGS2 gene were found to be associated in humans with anxious and depressive phenotypes. We sought to study the relationship of Rgs2 expression level to depression and anxiety-like behavioural features, sociability and brain 5-HT1A and 5-HT1B receptor expression. We studied male mice...
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