Article
RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 2010
Talbot Jeffery N, Jutkiewicz Emily M, Graves Steven M, Clemans Crystal F, Nicol Melanie R, Mortensen Richard M, Huang Xinyan, Neubig Richard R, Traynor John R
Abstract excerpt
Elevating serotonin (5-HT) levels with selective serotonin reuptake inhibitors (SSRIs) is the most widely used treatment for depression. However, current therapies are ineffective, have delayed benefit, or cause side effects in many patients. Here, we define a mechanism downstream of 5-HT1A receptors that mediates antidepressant-like behavior and is profoundly and selectively enhanced by genetic disruption of...
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